Holland, 26, threw one inning on Thursday night for Double-A Northwest Arkansas, striking out all three batters he faced. The right-hander threw 11 of his 14 pitches for strikes.
It was Holland's second strong rehab appearance while testing the rib injury that put him on the DL. Yost said Holland likely will return Saturday, barring anything crazy happening in the series opener.
"I would imagine, but if something happens [Friday] we'll have to wait and see," Yost said.
Holland is 0-2 with a 11.37 ERA in seven appearances this season, the last of which came on April 20, when he allowed three runs on three hits and two walks against the Blue Jays.
Yost said Holland will return to his regular late-inning role and "should be a big boost to our 'pen."