It will be Chen's 19th start of the season, which leads the Royals. Chen will be making his first appearance of the season against the White Sox, a team he went 3-1 against with a 1.89 ERA last year in five starts.
Right-hander Luke Hochevar will start on Saturday. Hochevar threw a full side session Sunday morning and reported no issues with his sprained right ankle.
Right-hander Luis Mendoza will close out the series next Sunday.