The victory, which gaves the Storm Chasers a 2-1 lead in the best-of-five series, came after a two-hour, three-minute rain delay. The game didn't finish until 12:41 a.m. MT on Saturday.
Seratelli homered and Max Ramirez knocked a two-run single in the top of the third. Maier's two-run shot in the seventh put the Storm Chasers ahead, 5-0, and they added one more in both of the final two innings.
The Isotopes scored once in the seventh and added three in the eighth before Omaha's Roman Colon walked one in a scoreless ninth to earn the save.