Crisp appeared to have problems swinging in the third inning and struck out against Tigers right-hander Edwin Jackson. Manager Trey Hillman will keep him out of Wednesday afternoon's series finale.
"His shoulder's barking," Hillman said. "Coco never begs out, never wants out. I made the decision for him. Sometimes you're just beating your head against the wall when you're trying to force something when a guy has some soreness and stiffness in there."
Although Crisp has been bothered by a sore shoulder periodically since Spring Training, he'd played in 44 of the Royals' 46 games. Crisp is batting .233 and leads the club in runs (29), walks (27), stolen bases (11) and triples (five).
"It got a little worse three weeks to a month into the season," Hillman said. "There was some soreness, but not as much as there has been recently."
Mitch Maier replaced Crisp in center field and contributed a two-run single to a 6-1 victory. Maier is likely to play center field Wednesday.
Hillman also got Crisp out of Monday's lopsided loss after six innings to rest the shoulder.
"It didn't seem to do a whole lot of good, and we might be looking at a little bit longer break," Hillman said. "Rest him tomorrow, and then we've got the day off [Thursday]. That makes sense, and then we'll have to check it."
Dick Kaegel is a reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.