The 6-foot-5 220-pound Reed had eight victories for Northwest Mississippi and set a school record of 96 strikeouts in 73 1/3 innings. He had 15 strikeouts in a one-hit shutout against Coahoma.
Signed for close to his slot figure of $1,198,500, Reed will report to minicamp at Surprise, Ariz., and then be assigned to the Idaho Falls Chukars in the Rookie Advanced Pioneer League.
He was the Royals' third choice and the 46th selection overall in the First-Year Player Draft on Thursday. Their No. 2 pick, left-handed pitcher Sean Manaea of Indiana State, has not yet signed. He was the 34th overall selection, going in the Competitive Balance Round. Manaea is headed for hip surgery, which would keep him out until next season.
The Royals had 41 selections in the Draft, which ended on Saturday.
Fifth-round selection Amalani FukoFuka, a center fielder from James Logan High School in Union City, Cal., batted .390 with 15 stolen bases and 22 runs scored.
Sixth-rounder Luke Farrell, son of Red Sox manager John Farrell, was picked 174th overall. The right-hander posted a 2.13 ERA, good for second in the Big Ten, while at Northwestern. He ranks eighth in program history with 80 strikeouts and third in opponent batting average with .202 in conference games.
Ninth-round selection Daniel Rockett, an outfielder from University of Texas at San Antonio, was picked 264th overall. He had a .328 batting average with 66 hits and 39 runs in 48 games.
Other players inking deals include: 12th-round pick Brandon Dulin, a first baseman from Longview College; 13th-round selection Jonathan Dziedzic, a left-handed pitcher from Lamar University; 14th-round pick Chase Darhower, a right-handed pitcher from Northwest Florida State College; 15th-round selection Dominique Taylor, a center fielder from UC-Irvine; 16th-round selection Kevin McCarthy, a right-handed pitcher from Marist College (NY); 17th-rounder Kevin Perez, a right-handed pitcher from Miami Dade Community College; 18th-rounder Frank Schwindel, a catcher from St. John's University; 20th-round selection Glenn Sparkman, a right-handed pitcher from Wharton County Junior College; 22nd-round pick Andrew Brockett, a right-handed pitcher from the University of Richmond; 24th-rounder Riley King, a center fielder from Carroll College (MT); 28th-round selection Kevin Kuntz, a shortstop from the University of Kansas; 29th-round pick Alex Black, a right-handed pitcher from Columbia University; and 30th-round selection Andrew Ayers, a second baseman from Sacramento State University.