"My focus for Jeremy is to get his work in and give Lamb a shot to go over there and pitch two or three innings," manager Ned Yost said.
Lamb, once a top prospect who has been slow coming back from Tommy John surgery, showed good velocity in a two-inning stint against the Cubs on Sunday. He gave up one run on two hits.
Guthrie worked his first two innings on Monday, giving up three runs on four hits. Yost expects him to throw about three innings or 50 pitches in the simulated game.
Dick Kaegel is a reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.