That included Mike Aviles moving into second base for Chris Getz and Yuniesky Betancourt returning to shortstop and Willie Bloomquist replaced David DeJesus in right field.
"Lefties haven't had too much production off of Mr. Harrison so it's a good day to give Getzy a day off. We'll see how the lineups flow through this series," Hillman said, aware that lefty C.J. Wilson starts for the Rangers on Friday night.
Harrison had held left-handed hitters to a .192 mark this season as opposed to .280 for righties. The only lefties in the Royals' starting lineup were outfielders Scott Podsednik and Mitch Maier.